Diag2Tec provides advanced, human-relevant platform to investigate normal B-cell to plasma cell differentiation, enabling the evaluation of therapeutic strategies in multiple myeloma and autoimmune diseases.
Diag2Tec provides advanced, human-relevant platform to investigate normal B-cell to plasma cell differentiation, enabling the evaluation of therapeutic strategies in multiple myeloma and autoimmune diseases.
Physiologically Relevant Model
The memory B-cell to plasma cell differentiation model recapitulates key maturation stages, from activated B cells to antibody-secreting plasma cells. This system enables the study of plasma cell biology, immunoglobulin production, and cellular dynamics in both normal and disease-relevant contexts. It is particularly relevant for multiple myeloma, as well as autoimmune disorders driven by pathogenic antibody production.
Mechanistic and Functional Readouts
We offer a wide range of assays, including:
- Phenotyping profiling by multiparametric flow cytometry,
- Differentiation and proliferation monitoring (multiparametric flow cytometry, cell count/viability),
- Ex vivo drug sensitivity on the different subsets of cells and on the differentiation process (multiparametric flow cytometry)
- Specific immune-mediated assays (ADCC, ADCP, CDC),
- Immunoglobulin secretion profiling on the different subsets of cells (Multiplex Elisa)
- Cytokines and other soluble factor analysis (Elisa, Proteomic assays)
- Genomic characterization at baseline and/or after treatments,
Deliverables
Comprehensive, decision-ready data packages, including detailed reports and raw/processed datasets, to support preclinical and translational research.